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Endocrine Discussion (Initial Posting Due) 3636 unread replies.3636 replies. Please refer to the course calendar for due dates for initial and response post. 1. Discuss the pathophysiologic difference between diabetes mellitus type 1 and diabetes mellitus type 2. 2. Describe the role of insulin in the metabolism of glucose, fat, and protein. Also, discuss how insulin is related to the manifestations of diabetes. Be sure to address both questions.